Diabetic Carrying Case

Grey Dhaka case medium VAT Relief. Brand New diabetic carrying case for your diabetes supplies.

Amazon Com Usa Gear Diabetic Supply Carrying Case With Insulin Travel Case Cooler Organizer For Blood Glucose Monitoring Systems Pens Syringe Case Insulin Case More Black Insulin Cooling Case

Shop online for diabetes supply cases diabetes bags and diabetes accessories.

Diabetic carrying case. Our products are designed by people with diabetes. These bags have specialized compartments where you can store your glucose meter case lancing devices medications and tests strips If you use insulin you will need an insulin pen carrying case or insulin. Shop online for diabetes supply cases diabetes bags and diabetes accessories.

This has different small pockets inside which helps you keep your different meds or the Insulin shots as per your liking. Browse through our wide selection of kitbags and cases to keep your insulin and other supplies safe and cool and transport securely. About 45 of these are cooler bags 13 are other special purpose bags cases and 10 are medical cryogenic equipments.

169916991699Count 5 coupon applied at checkoutSave 5with coupon. Our selection of diabetic pump holders and insulin pump cases for adults and children will provide peace of mind when you are carrying your insulin pump around with you throughout your day. Diagnosed at 24 years old our founder became discouraged by the diabetes products available.

Grey Dhaka case medium. She designed stylish diabetes organizers in. It keeps the whole pack of insulin cold for 24 hours straight and it stays on 48 degrees Fahrenheit approx.

Our products are designed by people with diabetes. 86NEURONS - Diabetes Supplies Bag and Insulin Travel case. A wide variety of diabetes carrying case options are available to you such as plastic polyester.

Diabetic Care Organizers Travel Kits. Black Dhaka case medium VAT Relief. However in being either vain or private I wanted it to be discrete.

This case allows you to carry and protect your glucose meter in a Nylon Case. She designed stylish diabetes organizers in. 46 out of 5 stars.

A New Diabetic Supply Carrying Case. You can also choose from reach diabetes carrying case as well as from case diabetes carrying case and whether diabetes carrying case is brown or silver. Diagnosed at 24 years old our founder became discouraged by the diabetes products available.

Insulated Carrying case and Organizer Pack for All Diabetic Supplies. A diabetic supply case organizer will come in handy in such situations For non-insulin users diabetic carrying cases will come in handy. CuraLin Type 2 Diabetes Supplement - Natural Ayurvedic Glucose Blood Sugar Advanced.

Holds Insulin pens vials Blood Sugar Test. The day after I was released from the hospital after my diagnosis of being a Type 1 Diabetic I looked over my syringes vials test strips lancets logbook and other such supplies and decided I needed some sort of carrying case. SHBC Insulin Cooler Travel Case for Diabetic Organize Medication Insulated Cooling Bag with 2.

Shop online for diabetes supply cases diabetes bags and diabetes accessories. 46 out of 5 stars. Youll appreciate the extra security and protection that your insulin pump carrying case provides.

Save on diabetes test strips glucose meters lancets and more from trusted brands such as FreeStyle OneTouch Ultra Accu-Chek Bayer Prodigy TRUEtest many more. Luxja Diabetic Supplies Travel Case Storage Bag for Glucose Meter and Other Diabetic Supplies Bag Only Purple. We offer affordable diabetic supplies at up to 60 below retail pricesespecially for people who are uninsured under-insured or must pay out of pocket.

Diagnosed at 24 years old our founder became discouraged by the diabetes products available. This sleek and stylish scratch water resistant case lets you carry your supplies wherever you go. Price2499 Read More Blue Nylon Cube Hard Shell Protective Carrying Case for Diabetic Organizer Carrying Case Kit December 25 2014 Comments Off on Blue Nylon Cube Hard Shell Protective Carrying Case for Diabetic Organizer Carrying Case Kit Designed to be small compact and easily accessible our Sumaclife Protective Case Cover for Diabetic Kits is the perfect companion to store your Blood Glucose Monitors Insulin Injectors Lancets Test Strips and other diabetic.

Our products are designed by people with diabetes. Diabetic Supplies Travel Case Simboom EpiPen Carrying Medical Case Insulated Holds 3 EpiPens Glucose Meter Asthma Inhaler Allergy Medications for Kids and AdultsBag Only-Gray. The padding protects your meter from bumps scratches spills and every day wear and tear.

This diabetic carrying case is meant to keep your insulin cold and safe from the outside temperature. She designed stylish diabetes organizers in. Black Dhaka case medium.

Insulin Pump Holder Considerations.

How Long Does It Take To Recover From Pneumonia

Some people feel better and able to return to their normal routines within a week. For others recovery will likely be slower taking a month or more.

The Effects Of Pneumonia On The Body

Another study surveyed 500.

How long does it take to recover from pneumonia. Dont rush your recovery. We know how long on average it takes for the virus to clear but that doesnt mean recovery it just means the virus is no longer detectable in your upper airway secretions. Some people feel better and are able to return to their normal routines within a week.

Pneumonia is an infection of the lungs in which the air sacs fill with fluid or pus. Recovering from pneumonia is a gradual process. Pneumonia can be a serious illness that takes weeks or months to recover from.

But full recovery. Recovery times vary a lot from person to person and depend on your general health age and how severe your pneumonia is. For many the recovery time takes a few weeks but if you have bacterial pneumonia it may also take up to a month to feel OK again.

After one gets affected with the organism which causes pneumonia it can take anywhere between a day to 10 days for symptoms to surface. Ninety days after diagnosis 51 percent reported fatigue 32 percent cough and 28 percent shortness of breath. Pneumonia takes a toll on the immune system and the longer it sticks around the higher the risk of complications with pre.

Once you start taking antibiotics your symptoms should begin to improve. The severity and recovery time for pneumonia is different for everyone but it can take anywhere from one week to six months. If you are diagnosed with pneumonia and your symptoms dont improve in 48 hours or if they get any worse call 111 or.

Full recovery from community-acquired pneumonia meaning cases caught outside a hospital setting takes an average of 21 days in adults over the age of. Get adequate rest and follow your doctors guidance on when to return to a normal routine. Some people who were diagnosed with bacterial pneumonia will actually feel better within a week.

Normal recovery time from pneumonia is one to three weeks though you should begin to feel better after several days of antibiotics. For other people it can take a month or more. So lung damage is not an overnight recovery and pneumonia can take up to several weeks or months of recovery especially for those who required significant oxygen supplementation Prof.

In very severe cases COVID-19 pneumonia can lead to acute respiratory distress syndrome ARDS. How Long Will It Take to Recover from Pneumonia. Pneumonia is a potential complication of COVID-19.

Jenkins says the lingering symptoms of pneumonia vary a lot depending on the severity of it. Once you start treatment you should experience improvement in your pneumonia symptoms pretty quickly within 48 hours or so. The standard is to continue antibiotics for one week past evidence that the pneumonia has cleared up on x-rays.

It may take time to recover from pneumonia. Recovery Time for Pneumonia It usually takes at least 3-5 weeks to recover from pneumonia. Normally patients develop chest discomfort pain with breathing and other breathing problems.

Most people continue to feel tired for about a month. Full recovery Remember recovery varies drastically depending on who is infected and the type of pneumonia the timeframes above do not apply to all cases. Read on to learn more about pneumonia and how long pneumonia lasts.

For healthy people suffering from pneumonia it is like a case of general illness which takes at most a fortnight to get cured. Adequate rest is important to maintain progress toward full recovery and to avoid relapse. If symptoms persist for a week after you have begun taking.

So lung damage is not an overnight recovery and pneumonia can take up to several weeks or months of recovery especially for those who required significant oxygen supplementation. Your dog will likely need to be on antibiotics for at least 4 weeks.

What Does A Heart Blockage Feel Like

So heart blockage heart attack coronary theyre all referring to exactly the same thing and what it feels like is the sudden onset of severe chest pain with breathlessness and sweating. Another abnormal condition that a person can face while suffering from heart blockage is fatigue.

Heart Attack Causes Symptoms Causes Treatment How To Prevent

The least serious type 1st-degree heart block.

What does a heart blockage feel like. How is heart block diagnosed. Signs and symptoms depend on how severe your heart block is. Called carotid artery disease you experience the symptoms of a stroke including if these major arteries are narrowed or blocked it can lead to numbness.

You may not have any symptoms or you may have any of the following. An anxiety attack for instance can result in chest pain shortness of breath and sweating. When the heart does not pump enough blood you may have difficulty breathing especially when engaged in certain strenuous activity.

Extreme cases of heart blockage which go unnoticed and without proper medical care can even cause heart failure or. Thats what happened the one time I went to the ER. An EKG will be.

The person can feel extremely tired worn out exhausted and low in energy. What are the signs and symptoms of heart block. Although an anxiety attack.

Sounds like you had a blockage and it cleared on its own. Its caused by a problem with the electrical pulses that control how your heart beats. Depending on the severity of the heart block this can be dangerous.

Although after the worst one I felt lousy for several hours after it cleared. My heart feels essentially blocked. This is a symptom that can occur in any age group but is more common in old people.

You breathe in and out thousands of times a day and rarely give it a thought -- until it starts to feel hard. Lightheadedness dizziness or fainting. Heart block typically causes lightheadedness fainting and palpitations.

Genetic abnormalities high cholesterol high blood pressure diabetes s. Heart blockage is condition when arteries may reduce or completely cut off the blood supply to a portion of the heart. If the blockage is gradual however pain may occur only during physical exertionplaying tennis for example.

Feeling nauseous is more likely to be experienced by a woman than a man when going through a heart blockage. What I found strange was that wthe blockages there were a few times that I felt horrible and nauseous and then instantly better when it cleared. Breathing problems can happen for many reasons like being out of shape congestion.

Symptoms of Blocked Arteries in the Arms. So heart blockage heart attack coronary theyre all referring to exactly the same thing and what it feels like is the sudden onset of severe chest pain with breathlessness and sweating. Professor David Celermajer is Scandrett Professor of Cardiology and.

It feels like oxygen not flowing n like it cant relax n. Complete heart block is a type of electrical issue that makes it impossible for electrical signals to travel from the atria the top two chambers of the heart to the ventricles which are. As in the legs the blockage may eventually stymie nail or hair growth.

See a doctor right away if you have severe symptoms like chest pain 6 what is that feeling of heart flutter in my chest. Feeling out of breath and getting chest pain is experienced by both sexes although this could indicate a heart artery being blocked which is mostly reported by women as a sign. It will probably be tender for a while next day or two.

It important to understand does no. This can be accompanied by nausea extreme weakness and fatigue. Cholesterol accumulation inflammation and ultimately blood clot formation.

Uncomfortable pressure fullness squeezing or pain in the center of the chest lasting more than a few minutes. Symptoms that feel like a heart attack may also signal other conditions. This degree of narrowing is associated with significantly reduced blood flow to the heart muscle and can underlie symptoms such as chest pain and shortness of breath.

Severe heart blockage is typically that in the greater than 70 range. Symptoms depend on which type of heart block you have. Professor David Celermajer is Scandrett Professor of Cardiology and.

To mix n its even more potassium. Heart block is a condition where the heart beats more slowly or with an abnormal rhythm. Healthcare providers will try to find the cause of your heart block.

Send thanks to the doctor. Like the legs the arms exhibit intense pain or numbness pallor and lack of pulse if a blockage happens suddenly. Those are symptoms and signs of heart attack.

Heart feels tight and constricted. In the diagram above an 80 blockage can be seen at the beginning of the vessel.

Best Phone For 9 Year Old

The Jitterbug Flip was designed for and is marketed to older users but the same features that make it a great phone for Grandma mean its also a good phone for younger users too. Does your kid have a special kid phone.

The Best Kids Phones For 2021 Pcmag

Just dont expect too much in terms of performance and display.

Best phone for 9 year old. Its an affordable entry-level smartphone that can be a good tool for teaching your kids how to safely use a. The best phones for ages 9-13 Best Parental Controls. The phone features a 62-inch HD display the Snapdragon 632 processor 2GB of RAM 32GB of expandable storage a.

It can also receive and send short messages seven of which come pre-written. KidiBuzz is an established kids electronics toy company so its no surprise this phone comes preloaded with 44 games that explore math science and spelling and allows kids to take photos and. - Pricey for a flip phone - US only The Lively Flip is a basic flip phone with features made to suit seniors well.

Because of its open system you can install a 2G GSM SIM card and use it to make phone calls. The new Samsung Galaxy Note 20 Ultra 5G is probably the best enterprise phone available today but the previous Galaxy Note 10 Plus is still worth. MONQI KIDS SMARTPHONE SOFTWAR This smartphone app designed to be a closed ecosystem specifically for children will give every kid that adult phone feeling without any of the risk.

It doesnt have any of the smartphone functionality a more tech-savvy senior might. Its durable reliable and has a long battery life that will keep your kids in communication. The Funntech Smart Watch for Kids stands out from the rest with its style and performance.

Fine for calls texts checking email and web browsing but multiple app use will slow things down. Compact good looking and a snug fit in a smaller hand the Alcatel Pixi 4 is a solid smartphone for kids. The 9 Best Cell Phones for Seniors in 2021 Make sure your loved ones are always in touch.

I wouldnt recommend paying the full 250 price from Samsung for this two-year-old handset in 2021 but found for much less it can be a decent no-frills budget option. Phones that look grown-up but offer limited features or that come with a service that allows you to customize options are good choices for older kids. One of the best phones for kids has to be the Nokia 3310 view on Amazon.

The Moto E is also an all-around decent option. When we tested the device we found that it lasted up to seven hours of screen time the camera set up performed well in most situations and the higher refresh rate on the screen made for. If youre looking for a smartphone with internet capabilities check out the Motorola Moto G7 Play view on Amazon.

Take a look at the Kurio phone the Kajeet service the Just5 or the TracFone which cant download apps. Bluetooth S Pen and amazing note features. The A53 has all the same great points as the A72 but this one is the 2021 model.

Normal Blood Pressure And Heart Rate

High blood pressure with a low pulse has causes that include problems with heart circulation and some medicines. With most adults the normal blood pressure reading needs to be below the 12080 measurement.

Normal Blood Pressure High Pulse Rate Pregnant Normal Blood Pressure But High Heart Rate

Normal Blood Pressure Range.

Normal blood pressure and heart rate. This remains the golden rule for adolescents adults and older adults. Low Normal Blood Pressure. When blood pressure readings consistently range from 120 to 129 systolic and less than 80 mm Hg diastolic it is known as elevated blood pressure.

Give Your Clients the Power To Reach Their Long-Term Goals with The Myzone System. The top number known as the systolic BP is the amount of pressure that your heart pumps through your arteries and entire body. Blood pressure increases with age but normal blood pressure is 12080 mm Hg or lower.

My blood pressure is often higher when my heart rate is close to its usual resting rate about 50 beats per minute and lower when my heart is beating faster than that. Low blood pressure coupled with a high heart rate is normal when it happens momentarily like when we stand up but long-term it could signal a heart rhythm problem. Blood Pressure vs.

Where can I get my blood pressure measured. You can have your blood pressure measured by a doctor a nurse a pharmacist or at home with an approved machine. A normal blood pressure reading would be.

The normal BP reading is 12080. Heart Rate Blood pressure. Can the bodys demands that cause higher blood pressure be partially satisfied by a faster heart rate.

Treatment will depend on. Blood pressure is a two-part measurement expressed in a fraction like 12080 mm Hg. By examining this number it does not include those with issues of their blood vessels or have existing health conditions affecting the blood pressure.

How do I measure my blood pressure at home. Blood Pressure Heart Rate Chart Doctor Recommendations. Understanding the difference between blood pressure and pulse.

I have a normal blood pressure but a high pulse rate of over 100. They are two separate measurements and indicators of health. The first number is the systolic pressure which measures pressure against your artery walls when your heart contracts and pumps blood out.

Exercise Emotion Heart rate and Blood pressure. For people with high blood pressure HBP or hypertension theres no. Systolic pressure mm Hg Diastolic pressure mm Hg Pressure Range.

Blood pressure below 12080 mm Hg is considered to be normal. For adults a normal reading is less than 12080 mm Hg according to the American Heart Association. Ad The Myzone Heart Rate System Helps Transforming Your Gyms Group Sessions.

Normal Blood Pressure for Adults. 69 of Americans who have a first HEART ATTACK have blood pressure OVER 14090 74 of Americans who have a first CONGESITIVE HEART FAILURE have blood pressure OVER 14090 of Americans who have a first STROKE have blood pressure. While your blood pressure is the force of your blood moving through your blood vessels your heart rate is the number of times your heart beats per minute.

Blood pressure is measured in mmHg. High Normal Blood Pressure. Give Your Clients the Power To Reach Their Long-Term Goals with The Myzone System.

Blood pressure is the force of blood pushing against the walls of arteries. Starting at age 20 the AHA recommends a blood pressure screening at your regular healthcare visit or once every 2 years if your blood pressure is less than 12080 mm Hg. Ad The Myzone Heart Rate System Helps Transforming Your Gyms Group Sessions.

Everything was fine at my recent doctors appointment. Systolic blood pressure under 120 mm Hg Diastolic blood pressure under 80 mm Hg. First let me congratulate you on monitoring your blood pressure at home.

The bottom number is known as the diastolic BP is the amount of pressure in the arteries and body when your heart is at rest. Ive had dizzy spells and shortness of breath plus swelling in my ankles. In a large study in China those who had a high-normal resting heart rate of 80 bpm to 90 bpm had a 40 percent shorter lifespan than those with a desirable heart rate of 60 bpm to 69 bpm.

Blood pressure is the pressure blood exerts on the arteries as the heart pumps. However normal blood pressure is the measure that your doctor will use to diagnose whether or not you are in the healthy range.

High Blood Sugar Feeling

In addition to having elevated levels of glucose in the blood people with hyperglycemia often have glucose detected in their urine glycosuria. There are even more factors that can make you feel tired when you have high blood sugar from eating the wrong TYPE or AMOUNT of foods.

Handling High And Low Blood Sugar Levels

Over time high blood sugar can affect your blood flow and cause nerve damage that makes it hard for your body to heal wounds.

High blood sugar feeling. The main symptoms of hyperglycemia are increased thirst and a. Sadly some people especially suffering from diabetes are less concerned about their symptoms. Fruity smelling breath or sweat nausea and vomiting severe dry mouth trouble breathing weakness pain in the abdominal area confusion coma.

In order to clear the sugar from the blood your body will try to eliminate the sugar by urinating it out explains Dr. Hyperglycemia is a condition when the amount of glucose a simple form of sugar in the bloodstream is higher than normal. Early symptoms can include.

In fact fatigue tired feeling are pretty common in people with hyperglycemia or high blood sugar. People without diabetes rarely have blood sugar levels over 140 mgdL after a. Ordinarily urine contains no glucose because it is reabsorbed by the kidneys.

High blood sugar is commonly known as hyperglycemia. When your blood sugar goes too high your kidneys are working overtime to eliminate the excess of glucose and sugar from your blood. Having high blood sugar levels can be discomforting and many people wish to know what they can do to help to bring down high blood glucose levels.

Postprandial or after-meal hyperglycemia. Mild symptoms will be felt by a person if the blood sugar levels are consistently in the range of 200 mgdL to 350 mgdL in older people and 200 mgdL to 240 mgdL in children. You should call 911 or seek emergency medical attention if you experience any of the following signs and symptoms.

Increased urinary frequency increased thirst blurred vision headaches fatigue. You know your blood sugar is high and you shouldnt eat but youre starving. High blood sugar can make you dizzy because of the physiologic response to high glucose levels says Stacy Mitchell Doyle MD resident physician of FoodTherapyMD and long-time advocate of plant-based nutritional protocols.

This is blood sugar thats higher than 180 mgdL 2 hours after you eat. Your mouth is dry your skin is dry and your body feels bloated and full. We look at some of the options for lowering blood glucose in the short term.

There you go with the fatigue and the foggy-brained feeling. The pancreas releases insulin to bring glucose to the cells but because of the high amount of sugar the insulin response is excessive About 2 hours later so much sugar has been put into storage that you now have low blood sugar and are feeling weak shaky brain fog fatigue change in mood depression and cravings The body responds to this as an emergency so it dumps adrenaline. It may signal that something goes awry with the glucose metabolism in the body.

How does glucose metabolism work. As a result their health condition was getting worse.

Bone Marrow Fibrosis

In bone marrow biopsies stromal structural fibres are detected by reticulin and trichrome stains routine stains performed on bone marrow biopsy specimens in diagnostic laboratories. Bone Marrow Fibrosis and Early Hematological Response as Predictors of Poor Outcome in Azacitidine Treated High Risk-Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia.

The European Consensus On Grading Of Bone Marrow Fibrosis Allows A Better Prognostication Of Patients With Primary Myelofibrosis Modern Pathology

Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed.

Bone marrow fibrosis. Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states the deposition of reticulin and collagen fibrosis in. Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. It is a secondary change associated with such disorders as inflammation bone marrow necrosis bone marrow injury and disorders of myeloproliferation eg acute myeloid leukemia and.

You can think of the bone marrow niche as a comfortable bed with a soft mattress covered by blankets and pillows. Increased reticulin staining reticulin fibrosis is associated with many benign and malignant conditions while increased trichrome staining collagen fibrosis is particularly prominent in late stages of severe myeloproliferative diseases or following tumour metastasis to the bone marrow. Bone marrow fibrosis evaluated as reticulin fiber density RFD in bone marrow sections was evaluated at diagnosis via computer technology.

In a recent article by Campbell et al 1 published in Journal of Clinical Oncology a significant association between the degree of bone marrow BM fibrosis at diagnosis and progression of disease as well as risk of arterial thrombosis was found in patients with essential thrombocythemia ET. Pathophysiology and clinical significance of increased bone marrow stromal fibres. The most severe form is dyskeratosis congenita see eg 127750 characterized by early childhood onset of skin abnormalities bone marrow failure predisposition to malignancy and risk of pulmonary and hepatic fibrosisAdult-onset pulmonary fibrosis is the most common.

Bone marrow biopsy specimens in diagnostic laboratories. In non-technical terms it is a condition in which the place where blood cell precursors live becomes unfriendly. Im often asked to explain what exactly is bone marrow fibrosis.

Bone Marrow Fibrosis BMF a common morphological finding in trephine biopsies is observed with variable grades of severity in various lesions including primary as well as secondary myelofibrosis1 The study of pattern and extent of bone marrow Fibrous Tissue Content FTC is important not only in diagnosis but also in evaluation of prognosis2. In narrative descriptions of bone marrow fibrosis the term fibrosis should always be specified as either reticulin fibrosis or collagen fibrosis with the term collagen fibrosis being reserved for collagen identifiable by trichrome stain. Bone marrow fibrosis is a lesion characterized by an increase of reticulin fibers or reticulin and collagen fibers andor proliferating fibroblasts.

2012 Farlex Inc. Shortened telomeres can cause a wide variety of clinical features that constitute a phenotypic spectrum. An increase in fibres and in new bone results in disorganization of the bone marrow architecture dysplasia of the haematopoietic cell lines fibrosis of vessel walls and thereby impeded egress of mature cells from the bone marrow resulting in ineffective haematopoiesis peripheral cytopenia often the indication for the biopsy and possibly myeloid metaplasia which has been found in many.

A general term for the presence of increased reticulin in the bone marrow which causes spindling of the marrow cells. Receiver operating characteristic curve ROC was used to analyze the predictive value of RFD for relapse and survival status. Bone marrow BM is traditionally called bone marrow fibrosis or myelofibrosis MF 9.

It shows a step-wise evolution from a physiologically normal state through first minimal focal and latter on diffuse increase of reticulin fibers up to the formation of collagenous fibers in advanced stages of the process associated in some of the. Reda G Riva M Fattizzo B Cassin R Giannarelli D Pennisi M Freyrie A Cairoli R Molteni A Cortelezzi A Semin Hematol 2018 Oct554202-208. Bone marrow fibrosis is a common phenomenon and is observed in various pathological conditions such as myeloproliferative and myelodysplastic neoplasms leukemias lymphomas mastocytosis paroxysmal nocturnal hemoglobinuria plasma cell myeloma Gauchers disease granulomas metastatic tumors hyperparathyroidism chronic renal failure osteopetrosis autoimmune disorders and Pagets disease.

Kaplan-Meier method was used to estimate survival rates per subgroup. Systemic mastocytosis cancer carcinoma lymphoma myeloma myeloproliferative disorders HIV. Grading scales for the.

Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis.